Recent advancements in reflux (GORD) treatment focus on improving efficacy, minimizing side effects, and enhancing patient outcomes.
1. Medications:
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- PPI alternatives: Proton pump inhibitors (PPIs) are the mainstay, but their long-term use is linked to side effects like bone fractures and kidney disease. Newer, more targeted medications like potassium-competitive acid blockers(e.g., vonoprazan) show promise as alternatives with fewer side effects.
- H2 receptor antagonists: While less potent than PPIs, they remain an option for mild GORD and are less likely to cause long-term side effects2.
2. Endoscopic and Surgical Treatments:
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- Endoscopic fundoplication: Newer techniques using endoscopic devices to tighten the lower oesophageal sphincter (LES) are being refined as minimally invasive alternatives to surgery.
- Transoral incisionless fundoplication (TIF): A less invasive procedure that reshapes the LES to prevent reflux without incisions.
- Magnetic sphincter augmentation: A device (LINX) implanted around the LES that helps prevent reflux by augmenting the muscle’s function.
3. Lifestyle Modifications: Ongoing research supports tailored dietary interventions, weight management, and sleep positioning to help manage symptoms.
These innovations are improving GORD management, with the goal of reducing dependence on medications and improving long-term outcomes.
